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4 Important Topical Peptides For Your Facial Routine

4 Important Topical Peptides For Your Facial Routine-image1

Think back to the last television commercial you saw advertising the latest beauty product, telling you it will solve all your aging problems. They told you it had antioxidants and peptides.

We kinda know what antioxidants are, but what are peptides?   4 Important Topical Peptides For Your Facial Routine - antioxidant

I did some research on peptides for you but, forgive me if I struggled a little breaking down science talk to everyday normal language.  I found there are 4 topical peptides commonly used in  beauty products.  Decide for yourself if you want to add peptides to your anti-aging facial routine.

.What Are Peptides?

The name peptide comes from pepton [peptos: digested (Greek)].

4 Important Topical Peptides For Your Facial Routine-image2

Well, when two amino acids come together they produce a new little chemical we named peptide.  Here’s what it means in grown-up talk.

Peptides are short amino acid chains. 

Peptides occur naturally in the human body, functioning as cellular communicators.  For protein regulation, cell proliferation, cell migration, inflammation control, angiogenesis; the process of creating new blood vessels from preexisting blood vessel , and melanogenesis, the process of producing melansomes by melanocyte to create the pigment melanin.

Bioactive peptides typically contain  two to ten  amino acids.

Peptides in beauty products are considered skin care actives and they can fulfill several functions.  They can be used to reduce wrinkles with “Botox-like” effect, stimulating collagen, antimicrobial to treat acne, wound healing, even lighten or tan the skin.   

There are 4 topical types of peptides used as skin-care actives in beauty products.

Signaling Peptides  Signal Peptide

An enzyme proteases is produced when the skin is injured.  Proteases breaks down damaged tissue into different peptide fragments.  These peptide fragments act as messengers, signaling the skin to produce different types of tissue to promote healing.

I don’t know about you, but increase collagen production sounds good to me.   So adding  Signal Peptides to your skin care routine is absolutely a good idea.   They include an active amino acid arrangement that makes it possible to stimulate collagen protein.  Or prevent the formation of the wrong type of collagen resulting in scarring. 

Carrier Peptides  Carrier peptide

Carrier peptides act as facilitators.  They transport important trace elements, like copper and manganese, necessary for wound healing.  Copper is utilized by every cell and organ in the body, causing the creation of important copper-dependent enzymes. 

The human tripeptide GHK, discovered in 1973 as an activity in human albumin, a protein made by the liver, that caused old human liver tissue to synthesize proteins like younger tissue.   This protein keeps fluid from escaping out of blood vessels, nourishes tissues, and transports hormones, vitamins, drugs and substances similar to calcium all through the body.

Found naturally in the body, Copper peptide GHK-Cu combines the element copper with three amino acids, making it a tripeptide. 

 GHK-Cu has an abundance of regenerative and protective actions, including antioxidant, anti-inflammatory, can promote wound healing properties, and collagen stimulation.  Levels of tripeptide GHK-Cu in the body reduces with age.

 Manganese is an element of the antioxidant enzyme manganese superoxide dismutase (MnSOD).  Antioxidants like  MnSOD  neutralize or prevent free radicals damage.       Copper peptides, a carrier peptides, accelerates wound healing and skin repair.

An example of carrier peptide is Copper Tripeptide Complex  found in  Neova Night Repair Moisturizer and  Neova Power Defense serum.

Why is copper ingredients showing up in more and more skin and hair products?

Copper as a skin care ingredient, is worth its weight in gold. The metal has proven abilities to fight wrinkles, treat scars and combating hair loss—making copper important to healthy, glowing skin.

 One of the key function of copper is anti-inflammatory – it works by controlling inflammatory cytokines – and there is an increasing school of thought that inflammation brings on aging.

Copper's powers also covers hair growth.  It work on the follicle in two ways:

  1. Increase follicle cell proliferation yielding increased follicle size
  2. Decrease programmed follicle cell death, resulting in smaller follicles.

  Enzyme-Inhibiting Peptides   

Enzyme-inhibitor peptides perform directly or not directly to inhibit an enzyme.  The enzyme tyrosinase stimulates a darkening of the skin.  Using an enzyme-inhibitor peptides could be use to even-out skin tones or  prevent degradation of collagen protein fibers.

Research Study     Study group

During a 12-week period, subjects were instructed to apply a facial serum formulation containing the manganese peptide complex twice a day.  This resulted in their skin’s photo-damage changed from moderate to mild.   Manganese Tripeptide-1   A non-toxic inhibitor of melanin promotes even skin tone. Manganese found in Neova Serious Clarity 4X

Neurotransmitter-Inhibiting Peptides

Inhibits acetylcholine  -  Acetylcholine (ACh) is an organic chemical released by nerve cells to send signals to other cells.  Muscles are contracted by neurotransmitter release from neurons.

Cosmeceutical neurotransmitter inhibitor peptides penetrate skin and targeting facial muscles, causing the reduction and softening of wrinkles and fine lines.

An example of an inhibiting peptide is Tripeptide-3 found in Neova Total DNA Repair Serum


When you’re research your skin care products, pay attention to the peptides, make sure you are choosing  the correct ones to give you the results you want.

Are you located in Aiken SC.?


      Aiken SC.

Take advantage of my 25 years experience as a license Esthetician. 

Schedule an appointment for a private skin care consultation session.  

As your personal  “Skin Care Consultant”, I can assist you with  non-medical skin care advise.   Make recommendations on skin care products with the correct peptide ingredients necessary to achieve healthy youthful looking skin. 









Physiology of the Skin, 2001, Peter T. Pugliese, MD,
Gorouhi F, Maibach HI. Role of topical peptides in preventing or treating aged skin. International Journal of Cosmetic Science. 2009; 31: 327–345.
Topical Peptide Treatments with Effective Anti-Aging Results Silke Karin Schagen Beldio ; Published: 22 May 2017

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